Quick search:
Content Search
Result Content Research
Result Content Research
1 Gasdermin D pore structure reveals preferential release of mature interleukin-1
2 Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
3 Succination inactivates gasdermin D and blocks pyroptosis
4 NLRP3 inflammasome in rheumatoid arthritis pathophysiology | ITT
5 Calcitriol Alleviates Hyperosmotic Stress in iHCECs | JIR
6 A key player in cell death moonlights as a mediator of inflammation
7 Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway
8 Pyroptosis-related indicators as potential biomarkers | JIR
9 Samantha Truex's Quench Bio calls it quits after failing to solve the Gasdermin D inflammation puzzle
10 Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation
11 Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
12 Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
13 Coral gasdermin triggers pyroptosis
14 Preventing pores and inflammation
15 Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
16 Gasdermin D Hypermethylation Inhibits Pyroptosis And LPS-Induced IL-1b | ITT
17 Quench Bio hit by 'successful failure,' winds down ops in Twitter thread as tech sold off at auction
18 The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia
19 Role of Pyroptosis in Diabetes and Its Therapeutic Implications | JIR
20 Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS
21 Quench Bio Winds Down Operations Following 'Successful Failure'
22 Science Immunology
23 Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
24 Quench Bio emerges with $50M to treat severe inflammatory diseases
25 Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
26 Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting | DDDT
27 After winding down Quench Bio with a bold dose of honesty, Sam Truex finds 'perfect fit' at Atlas Venture
28 Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target
29 How human cells and pathogenic shigella engage in battle
30 Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases
31 Smothering the Fire | Harvard Medical School
32 Pyroptosis in cardiovascular disease | JIR
33 Deep-sea microbes as tools to refine the rules of innate immune pattern recognition
34 Sepsis Biomarker Prospect Found in Sugar-Binding Protein
35 How human cells and pathogenic shigella engage
36 New target identified for ZIKV-induced microcephaly
37 Ventus Therapeutics launches to drug inflammasomes, cGAS, and more
38 Response to pegylated interferon in a COVID‐19 positive male with metastatic jejunal neuroendocrine tumor treated with everolimus
39 Caspase-1 initiates apoptosis, but not pyroptosis, in the absence of gasdermin D
40 Severe acute pancreatitis-associated cardiac injury
41 The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6
42 Quench targets lupus and rare diseases with R&D into new drug class
43 Guardians of the Ring | Harvard Medical School
44 Developing Detection Tools for Gasdermin E
45 Disulfiram inhibits inflammatory gatekeeper protein—could it be helpful in COVID-19?
46 cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
47 ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
48 Pyroptotic cell death: Controlled self-destruct that causes inflammation and disease
49 Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
50 Study reveals details of immune defense guidance system: Results could lead to better drugs used to fight inflammation
51 A checkpoint for pyroptosis
52 Punicalin ameliorates cell pyroptosis induced by LPS/ATP thr | JIR
53 Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease
54 Destroying tumors with pyroptosis
55 Programmed cell death: The roles of caspase-1 and gasdermin D in apoptosis and pyroptosis
56 STINGing tumors with nanoparticles: New immunotherapy drug activates the body's innate immune system to fight cancer
57 PAF and the inflammasome
58 Novartis acquires inflammasome blocker company IFM Tre
59 Inhibition of the NLRP3 inflammasome prevents ovarian aging
60 New approach to severe bacterial infections and sepsis
61 IRF2 transcriptionally induces GSDMD expression for pyroptosis
62 Quench Bio Springs From Atlas With $50M for a New Take on Inflammation
63 Two Billion People Have a Brain Parasite – Here's Why Many Haven't Noticed
64 Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
65 How do cells release IL-1? After 3 decades, now we know: Surprising answer could help scientists build better vaccines, treat inflammation
66 New mechanism underlying pyroptosis induced by Yersinia infection
67 Quench Bio is named one of Fierce Biotech's "Fierce 15" Biotech Companies of 2020
68 Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediate | DMSO
69 MS: New findings may 'prevent future loss of brain cells'
70 cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
71 Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
72 Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
73 Casting NETs in SARS: Overactive Neutrophils in COVID-19
74 This Week in Science
75 Cell Death Protein also Damps Inflammation
76 Drugs targeting neutrophils could reduce ARDS in severe COVID-19
77 C&EN's 2020 10 Start-Ups to Watch
78 Schisandrin Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis i | NDT
79 Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells
80 Unusual Pain Disorders – What Can Be Learned from Them? | JPR
81 Could downregulating the Drp1 protein prevent Alzheimer's progression?
82 Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones
83 Cytokine Storm
84 Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyropto | IDR
85 Hole-forming protein may suppress tumor growth: Gasdermin E could be a useful target for improving cancer therapy
86 Type I interferon remodels lysosome function and modifies intestinal epithelial defense
87 Inflammasome as an effective platform for fibrosis therapy | JIR
88 Innate immunity during SARS‐CoV‐2: evasion strategies and activation trigger hypoxia and vascular damage
89 Why more people than ever are living with heart failure
90 Metabolites released from apoptotic cells act as tissue messengers
91 Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance | Scientific Reports
92 How do cells release IL-1? After three decades, now we know
93 New Regulators of Macrophage Pyroptosis
94 New pathway in body's immune response uncovered
95 Structure of the mycobacterial ESX-5 type VII secretion system pore complex
96 Activation and inhibition of the NLRP3 inflammasome by RNA | JIR
97 Unravelling an alternative mechanism of airway mucosal immunity
98 Killer cells add fire to fuel immunotherapy
99 Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity
100 Clockophagy is a novel selective autophagy process favoring ferroptosis